胰島素受體信號通路

胰島素受體信號通路

The appropriate signaling through the insulin pathway is critical for the regulation of glucose levels and the avoidance of diabetes. Insulin forms a complex with the Insulin Receptor (IR) and b chains to form the active signaling complex. Through recruitment of adaptor molecules and the activation of RAS, the activated IR can cause transcriptional activation.

Insulin receptor signaling pathway

AMPK參與葡萄糖代謝病與胰島素信號通路聯系

Insulin receptor signaling pathway

胰島素信號通路的多樣性

Pleiotropic insulin signaling pathways. CAP—c-Cbl-associated protein; IRS-1—insulin receptor substrate-1; MAPK—mitogenactivated protein kinase; PC-1—plasma Cell glycoprotein-1; PDK—phosphoinositide-dependent kinase; PKC—protein kinase C; PI3-K—phosphatidylinositol 3-kinase

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